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Epab and Pabpc1 are differentially expressed during male germ cell development.
Ozturk S, Guzeloglu-Kayisli O, Demir N, Sozen B, Ilbay O, Lalioti MD, Seli E. Ozturk S, et al. Reprod Sci. 2012 Sep;19(9):911-22. doi: 10.1177/1933719112446086. Epub 2012 Jul 18. Reprod Sci. 2012. PMID: 22814100 Free PMC article.
Embryonic poly(A)-binding protein (EPAB) and somatic cytoplasmic poly(A)-binding protein (PABPC1) are the 2 key proteins implicated in this pathway. In this study we characterized the temporal and spatial expression of Epab and Pabpc1 in immature (D6-D32) and mature …
Embryonic poly(A)-binding protein (EPAB) and somatic cytoplasmic poly(A)-binding protein (PABPC1) are the 2 key proteins implicated i …
Domain-functional analyses of PIWIL1 and PABPC1 indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs.
Wu Y, Xu K, Qi H. Wu Y, et al. Biol Reprod. 2018 Oct 1;99(4):773-788. doi: 10.1093/biolre/ioy100. Biol Reprod. 2018. PMID: 29701755
Using biochemical assays, we show here that PIWIL1 utilizes different domains to interact with post-meiotic mRNAs and Poly-A binding protein cytoplasmic 1 (PABPC1), a general protein translation regulator. PIWIL1 binds 3'-untranslated regions (3'-UTRs) of several spermioge …
Using biochemical assays, we show here that PIWIL1 utilizes different domains to interact with post-meiotic mRNAs and Poly-A binding protein …
The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia.
Ozturk S, Sozen B, Uysal F, Bassorgun IC, Usta MF, Akkoyunlu G, Demir N. Ozturk S, et al. J Assist Reprod Genet. 2016 Mar;33(3):335-348. doi: 10.1007/s10815-016-0654-z. Epub 2016 Feb 3. J Assist Reprod Genet. 2016. PMID: 26843391 Free PMC article.

The expression levels of cytoplasmically localized PABPC1 and PABPC3 proteins dramatically reduced from hyposperm to SCO groups (P < 0.05). In the isolated SC and RS fractions, the EPAB, PABPC1, and PABPC3 mRNA expressions were gradually decreased from hyposperm

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The expression levels of cytoplasmically localized PABPC1 and PABPC3 proteins dramatically reduced from hyposperm to SCO groups (P &l …
Potential roles of the poly(A)-binding proteins in translational regulation during spermatogenesis.
Ozturk S, Uysal F. Ozturk S, et al. J Reprod Dev. 2018 Aug 20;64(4):289-296. doi: 10.1262/jrd.2018-026. Epub 2018 May 18. J Reprod Dev. 2018. PMID: 29780056 Free PMC article. Review.
Studies in this field have revealed that PABPs, particularly poly(A)-binding protein cytoplasmic 1 (Pabpc1), Pabpc2, and the embryonic poly(A)-binding protein (Epab), play roles in the translational regulation of mRNAs required at later stages of spermatogenesis. ...
Studies in this field have revealed that PABPs, particularly poly(A)-binding protein cytoplasmic 1 (Pabpc1), Pabpc2, and the embryoni …
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma.
Zhang X, Vos HR, Tao W, Stoorvogel W. Zhang X, et al. Int J Mol Sci. 2020 Oct 26;21(21):7957. doi: 10.3390/ijms21217957. Int J Mol Sci. 2020. PMID: 33114768 Free PMC article.
Nevertheless, EV are also contributed by other accessory sex glands, as well as by the testis and epididymis. In a previous study, we isolated EV from seminal plasma of vasectomized men, thereby excluding contributions from the testis and epididymis, and identified …
Nevertheless, EV are also contributed by other accessory sex glands, as well as by the testis and epididymis. In a previous study, we …
Embryonic poly(A)-binding protein is differently expressed and interacts with the messenger RNAs in the mouse oocytes and early embryos.
Uysal F, Ozturk S. Uysal F, et al. J Cell Biochem. 2019 Mar;120(3):4694-4709. doi: 10.1002/jcb.27759. Epub 2018 Oct 9. J Cell Biochem. 2019. PMID: 30302808

While EPAB expression gradually decreased from GV oocytes to two-cell embryos, the PABPC1 protein level progressively increased from GV oocytes to one-cell embryos and remarkably declined in the two-cell embryos ( P < 0.05). We have also described herein that the EPAB p

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While EPAB expression gradually decreased from GV oocytes to two-cell embryos, the PABPC1 protein level progressively increased from …
Functional compensation for the loss of testis-specific poly(A)-binding protein, PABPC2, during mouse spermatogenesis.
Kashiwabara S, Tsuruta S, Okada K, Saegusa A, Miyagaki Y, Baba T. Kashiwabara S, et al. J Reprod Dev. 2016 Jun 17;62(3):305-10. doi: 10.1262/jrd.2016-023. Epub 2016 Mar 13. J Reprod Dev. 2016. PMID: 26971890 Free PMC article.
Mouse testes contain several isoforms of cytoplasmic poly(A)-binding proteins (PABPCs), including ubiquitous PABPC1 and testis-specific PABPC2/PABPt. ...The processes of spermatogenesis and sperm migration in the testes and epididymides, respectively, …
Mouse testes contain several isoforms of cytoplasmic poly(A)-binding proteins (PABPCs), including ubiquitous PABPC1 and tes …
Identification and characterization of human embryonic poly(A) binding protein (EPAB).
Guzeloglu-Kayisli O, Pauli S, Demir H, Lalioti MD, Sakkas D, Seli E. Guzeloglu-Kayisli O, et al. Mol Hum Reprod. 2008 Oct;14(10):581-8. doi: 10.1093/molehr/gan047. Epub 2008 Aug 20. Mol Hum Reprod. 2008. PMID: 18716053
Human EPAB is a 619 amino acid protein with 77% identity and 84% similarity to mouse EPAB. Human EPAB mRNA is detected in ovaries, testes and several somatic tissues including pancreas, liver and thymus. Similar to the observations in Xenopus and mouse, human EPAB is the p …
Human EPAB is a 619 amino acid protein with 77% identity and 84% similarity to mouse EPAB. Human EPAB mRNA is detected in ovaries, testes …
Polyubiquitin gene Ubb is required for upregulation of Piwi protein level during mouse testis development.
Han B, Jung BK, Park SH, Song KJ, Anwar MA, Ryu KY, Kim KP. Han B, et al. Cell Death Discov. 2021 Jul 26;7(1):194. doi: 10.1038/s41420-021-00581-2. Cell Death Discov. 2021. PMID: 34312369 Free PMC article.
Testis development, including early embryonic gonad formation and late postnatal spermatogenesis, is essential for the reproduction of higher metazoans to generate fertile gametes, called sperm. ...We also found that levels of piRNA metabolic process-related proteins, incl …
Testis development, including early embryonic gonad formation and late postnatal spermatogenesis, is essential for the reproduction o …
Intronless Pabpc6 encodes a testis-specific, cytoplasmic poly(A)-binding protein but is dispensable for spermatogenesis in the mouse.
Kaku Y, Isono Y, Tanaka H, Kobayashi T, Kanemori Y, Kashiwabara SI. Kaku Y, et al. Biol Reprod. 2024 Apr 11;110(4):834-847. doi: 10.1093/biolre/ioae017. Biol Reprod. 2024. PMID: 38281153
Besides ubiquitous poly(A)-binding protein, cytoplasmic 1 (PABPC1), testis-specific PABPC2/PABPt (in humans, referred to as PABPC3), and female and male germline-specific PABPC1L/ePAB, have been reported in the mouse testis. Recent in silico analysis addition …
Besides ubiquitous poly(A)-binding protein, cytoplasmic 1 (PABPC1), testis-specific PABPC2/PABPt (in humans, referred to as PA …
11 results